Aspects of Slow and Persistent Virus Infections

Slow, Latent, and Temperate Virus Infections

and Welfare, 1965. xx, 489 pp. $6.75 (but available free in paper covers on individual request to NINDB-presumably while supplies last!). In 1957, Gajdusek and Zigas first described kuru, a disease characterized by progressive ataxia, tremor and emotional lability, and confined to the Fore people of New Guinea and their nearest neighbors. In 1959, Hadlow pointed out the similarity in pathology ...

[Slow virus infections of the nervous system].

The term "slow infection" was coined originally in the veterinary literature to describe several trans­ missible diseases of sheep. 1 Two of these diseases, scrapie and visna, have become the prototypes of slow infection of the central nervous system (CNS). After inoculation of sheep with tissues from an in­ fected sheep, a latent period of one or more years ensues, during which the sheep appea...

General features of persistent virus infections.

Persistent virus infections are discussed from the virus point of view in terms of the bodily sites in which the infection persists. Glands and body surfaces are thought to be significant because they give the virus protection at the topographical level from immune forces, and because they are appropriate sites for the shedding of virus to the exterior. Germ cells are relevant sites because inf...

Virological aspects of Epstein-Barr virus infections.

Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). However, EBV has been linked to several refractory diseases such as EBV-associated hemophagocytic syndrome(EBV-AHS) and chronic active EBV infection (CAEBV). In these ectopic diseases, EBV infects T/NK cells, causing severe immunode...

Immune responses in persistent virus infections.